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Research

Biological Physics

actin cell

Biological physics is the study of physical processes that govern living systems, ranging from the molecular to the macroscopic scale. These interactions incorporate a diverse array of physics themes including force balance, adhesion, diffusion, energy transfer and non-equilibrium mechanics and drive biological processes such as shape change, tissue development and homeostasis. 

As an interface between multiple fields, the opportunities for research span a variety of broad approaches. Within the department there are the following research focus areas

Cellular Mechanics

Professor Patrick Oakes is a biological physicist who studies cellular force generation, in particular the cytoskeleton and its many associated proteins. His group is interested in how cells regulate and leverage mechanical interactions as signaling pathways to control processes like adhesion, migration, and cellular shape changes. His work incorporates quantitative high-resolution microscopy, image processing, optogenetics, and substrate engineering, with traditional biochemical and genetic approaches. 

Tissue Morphogenesis

Professor Dan Bergstralh and his research group study how single-cell behaviors, including division and cell-cell adhesion, are coordinated to build and maintain biological tissues. The lab uses high-resolution live-imaging to address this set of problems, and employs a range of biological systems that includes fruit flies (Drosophila melanogaster) and three-dimensional cultured tissue models. Professor Bergstralh’s lab is located in the Biology Department.

Medical Imaging

Professor Thomas Foster works on fundamental problems of photodynamic therapy. In this technique, radiation and chemical act locally with the help of oxygen to destroy cancerous cells. He studies this process at the molecular interaction stage and has made important advances in the quantitative aspects of this therapy. 

Professor Jianhui Zhong works on the use and development of magnetic resonance imaging (MRI) techniques for studying changes in biological tissues. Recent focuses of his work include modeling of reduced diffusion in brain ischemia, diffusion-weighted MRI for the detection of neuronal electrical activities, quantitative measurements of tumor oxygenation and flow, and the development of intermolecular multiple-quantum coherence (iMQC) MRI. 

Both Professor Foster and Zhong’s laboratories are in the University’s Strong Memorial Medical Center.

 

Additional Research Opportunities

Research opportunities in biological physics exist with faculty in other unit of the University.

Professor David Matthews is a theorist in the Department of Biochemistry and Biophysics in the University Medical Center. His group is interested in problems relating to the prediction of RNA structure from its sequence, using both low and high-resolution models.

Professor Louis Rothberg works on biomolecular sensing and develops new assays that are useful for clinical and research applications. These are based on optical or electrical detection of small quantities of unmodified oligonucleotides or important proteins, and are carried out in collaboration with researchers at the Medical Center.

Professor Alan Grossfield's interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, he is most interested in understanding the biology and physics of lipid protein interactions. These interactions underlie a fantastic array of biological processes, including cell signaling by GPCRs and some immune reactions, specifcially the action of antimicrobial peptieds. Professor Grossfield is with the Department of Biochemistry and Biophysics at the University of Rochester Medical Center.

The department also participates in the MD/PhD program at the University, enabling particularly well prepared students the opportunity to work simultaneously toward the MD degree and the PhD degree in physics.

Biological Physics Links